Epidermolysis bullosa acquisita–like reaction associated with penicillamine therapy for sclerodermatous graft-versus-host disease - 29/08/11
, Karel Pizinger, MD a, Alena Skálová, MD bAbstract |
A case of a bullous eruption occurred in a patient being treated with penicillamine for sclerodermatous graft-versus-host disease following bone marrow transplantation. After 7 days of treatment with 150 mg penicillamine, a painful bullous eruption with accompanying purpuric lesions suddenly developed in previous sclerodermatous infiltrations. A diagnosis of epidermolysis bullosa acquisita–like eruption was made, and the patient was treated with drug withdrawal and administration of cyclosporine and methylprednisolone. Epidermolysis bullosa acquisita–like reaction is an extremely rare cutaneous side effect of penicillamine. The surprisingly early onset of this eruption in lesions of sclerodermatous graft-versus-host disease might have been due to severe immune alteration.
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 | Funding sources: None. Conflict of interest: None identified. |
Vol 49 - N° 6
P. 1157-1159 - décembre 2003 Retour au numéro
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