Dermatophytoma: Recalcitrance to treatment because of existence of fungal biofilm - 01/09/11
Abstract |
Biofilms are populations of microorganisms that adhere to surfaces and produce an extracellular polysaccharide, increasing resistance to standard antimicrobials. This microbiologic principle may be beneficial in understanding refractory dermatophyte infections, such as dermatophytomas of the nail. In this condition, circumscribed dense white fungal masses live within and under the nail plate. Biofilm research could lead to finding new targets for antifungal therapy, including agents that reduce attachment of microorganisms, alter microorganisms' ability to synthesize extracellular matrix, and better penetrate the extracellular matrix to kill the organism contained with the biofilm. (J Am Acad Dermatol 2002;47:629-31.)
Le texte complet de cet article est disponible en PDF. | Funding sources: None. |
| Disclosure: The authors have no commercial associations, neither current nor over the past 5 years, that might pose a conflict of interest. There are no competing or conflicting interests. |
 | Reprint requests: Craig G. Burkhart, MD, MSPH, 5600 Monroe St, Suite 106B, Sylvania, OH 43560. E-mail: cgbakb@aol.com. |
Vol 47 - N° 4
P. 629-631 - octobre 2002 Retour au numéro
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