Effectors of inflammation in actinic prurigo - 02/09/11
Abstract |
Background: Actinic prurigo is a specific familial photodermatosis of uncertain pathogenesis. Objective: Our purpose was to investigate the immunohistologic presentation of actinic prurigo to explore the involved pathomechanisms. Methods: The present immunohistochemical study was performed on biopsy specimens from 20 Mexican patients presenting with a severe and perennial form of the disease. Results: The dense inflammatory infiltrate was composed predominantly of helper T type 1 lymphocytes admixed with scattered B-cell lymphoid follicles and numerous dermal dendrocytes. Keratinocytes contained abundant tumor necrosis factor-⍺ and calprotectin. Conclusion: In subjects genetically predisposed to actinic prurigo, ultraviolet light may trigger excessive tumor necrosis factor-⍺ production by keratinocytes whose sustained release in turn exerts its proinflammatory activity and deleterious epidermal effects. Such a cascade of events is in line with the therapeutic benefit already reported when thalidomide is used to treat actinic prurigo. (J Am Acad Dermatol 2001;44:957-61.)
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Reprint requests: G. E. Piérard, MD, PhD, Department of Dermatopathology, CHU Sart Tilman, B-4000 Liège, Belgium. E-mail: Gerald.Pierard@ulg.ac.be. |
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J Am Acad Dermatol 2001;44:957-61 |
Vol 44 - N° 6
P. 957-961 - juin 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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