Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosis - 02/09/11
Doi : 10.1067/mjd.2001.112403
Hisashi Takayama, MD a, Yoji Nagashima, MD c, Masamichi Hara, MD d, Hitoshi Takagi, MD a, Masatomo Mori, MD a, Glenn Merlino, PhD e, Yoichi Nakazato, MD b
a First Department of Internal Medicine
b First Department of Pathology
c Gunma University School of Medicine, Maebashi; the Department of Pathology, Yokohama City University School of Medicine
d Division of Laboratory Medicine, Yokohama City University Urafune Hospital
e Yokohama; and the Laboratory of Molecular Biology, National Cancer Institute, Bethesda
Abstract |
Transgenic mice overexpressing hepatocyte growth factor/scatter factor (HGF/SF) demonstrate extensive pigmented nevi in both skin and leptomeninges of the central nervous system resembling human neurocutaneous melanosis. We immunohistochemically detected HGF/SF receptor, Met, in a congenital nevus of an infant with neurocutaneous melanosis, indicating that deregulation of HGF/SF-Met signaling in the critical period of development may lead to this fatal syndrome. (J Am Acad Dermatol 2001;44:538-40.)
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 | Supported in part by grants from the Ministry of Education, Science and Culture, Tokyo, Japan. |
| Reprint requests: Hisashi Takayama, MD, First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan. E-mail: hitakaya@showa.gunma-u.ac.jp. |
© 2001
American Academy of Dermatology, Inc. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 44 - N° 3
P. 538-540 - mars 2001 Retour au numéro
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