Vohwinkel's syndrome in three generations - 02/09/11
Abstract |
Vohwinkel's syndrome or keratoderma hereditaria mutilans is a diffuse, honeycombed, palmar, and plantar keratosis usually accompanied by pseudoainhum near the distal interphalangeal creases. The mutilating keratoderma associated with sensorineural hearing loss is thought to have an etiologic basis, resting on a mutation of the GJB2 gene, which encodes the gap junction protein connexin26 (Cx26). This specific mutation results in impaired epidermal differentiation as well as inner ear function. We describe a patient with Vohwinkel's syndrome accompanied by high-frequency sensorineural hearing loss whose mother and son were similarly affected. (J Am Acad Dermatol 2001;44:376-8.)
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This supplement is made possible through an educational grant from Ortho Dermatological to the American Academy of Dermatology. |
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J Am Acad Dermatol 2001;44:376-8 |
Vol 44 - N° 2P2
P. 376-378 - février 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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