Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans after the application of cinnamic aldehyde - 02/09/11
Abstract |
Background: Cinnamic aldehyde is a common fragrance additive in foods and various health and beauty products. Application of cinnamic aldehyde to the skin of humans can induce cutaneous vasodilatation characterized by erythema, urticaria, and stinging. Previous studies have suggested that prostaglandins (PGs) may mediate the vasodilation, but the causative PG has not been established. We have shown that cutaneous vasodilatation induced by compounds such as sorbic acid and methylnicotinate is mediated by PGD2. Objective: Our purpose was to determine whether cutaneous vasodilatation induced by cinnamic aldehyde is mediated by PGD2 in humans. Method and Results: Topical application of 1% cinnamic aldehyde to the forearms of 3 human volunteers resulted in cutaneous flushing and 25- to 42-fold increases in the levels of the major circulating metabolite of PGD2, 9⍺, 11β-PGF2, in blood drawn from the antecubital vein draining the treated sites. There was no increase in other vasodilatory mediators, including PGE2, PGI2, or histamine. The release of PGD2 was concentration dependent. Cutaneous vasodilatation and PGD2 release were markedly decreased by the administration of aspirin, but were not significantly altered by pretreatment with the selective cyclooxygenase-2 inhibitor rofecoxib, suggesting that the formation of PGD2 is dependent on cyclooxygenase-1. Conclusion: The cutaneous vasodilatation induced by cinnamic aldehyde is mediated to a large extent by the release of PGD2 from a cellular source in the skin. (J Am Acad Dermatol 2001;45:62-7.)
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Supported in part by grants DK48831, GM15431, CA77839, and DK26657 from the National Institutes of Health. Dr Morrow is the recipient of a Burroughs Wellcome Fund Clinical Scientist Award in Translational Research. |
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J Am Acad Dermatol 2001;45:62-7 |
Vol 45 - N° 1
P. 62-67 - juillet 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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