Phototesting in lupus erythematosus: A 15-year experience - 02/09/11
Abstract |
It has long been observed that sun exposure can induce or exacerbate skin lesions in patients with certain forms of lupus erythematosus. Despite the frequency of photosensitivity in these patients, the mechanism by which ultraviolet radiation alters the pathogenic course of this disease remains poorly understood. After development of standardized test methods, our group demonstrated in 1986 that skin lesions in patients with lupus erythematosus can be experimentally reproduced by UVA and UVB irradiation. In the following years, phototesting has received much attention as a valid model to study photosensitivity of different forms of lupus erythematosus and the pathogenetic mechanism of this disease. Further investigations have also made it possible to find genetic and immunologic factors associated with photosensitivity and have helped to identify the pathophysiologic steps involved in the induction of such skin lesions. We present phototesting results and clinical correlations of more than 400 patients with different forms of lupus erythematosus and discuss the recent advances in provocative phototesting. (J Am Acad Dermatol 2001;45:86-95.)
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Supported by a Lise-Meitner scholarship and a research grant of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (to A. Kuhn). |
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Reprint requests: Annegret Kuhn, MD, Institute of Cell Biology, ZMBE, Westfälische Wilhelms-University, Von-Esmarch-Strasse 56, D-48149 Münster, Germany. |
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J Am Acad Dermatol 2001;45:86-95 |
Vol 45 - N° 1
P. 86-95 - juillet 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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