Familial occurrence of adiposis dolorosa - 02/09/11
Abstract |
Adiposis dolorosa is a rare condition characterized by multiple painful lipomas. We describe two typically affected siblings who were found to have at least 5 affected first-degree relatives in two generations. Manifestations were remarkably variable, ranging from complete disability to solitary asymptomatic tumors. Review of histopathologic findings did not reveal any features that might distinguish the tumors from common sporadic lipomas. Mutational analysis excluded the 8344 A to G mitochondrial mutation seen in other patients with multiple lipomas. Adiposis dolorosa may be an extreme manifestation of the more common condition of familial multiple lipomas. Further work is needed to define the genetic basis of these conditions. (J Am Acad Dermatol 2001;44:132-6.)
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Supported by grant R01NS35878-02 from the National Institutes of Health (to M. M.). |
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Reprint requests: Mia MacCollin, Neuroscience Center, MGH-East, Bldg 149, 13th St, Charlestown, MA 02129. E-mail: maccollin@helix.mgh.harvard.edu. |
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J Am Acad Dermatol 2001;44:132-6. |
Vol 44 - N° 1
P. 132-136 - janvier 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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