Isotretinoin effects on bone - 02/09/11
Abstract |
Isotretinoin has demonstrated efficacy in a wide range of disorders. The beneficial effects of the drug, however, are limited by its adverse effects on the bone. Children exposed to high doses are at risk for premature epiphyseal closure, while adults on long-term therapy have an increased tendency to develop hyperstosis and other changes of the bone. The knowledge of these effects, in conjunction with continued surveillance, are necessary for expert management and can ensure many years of efficacious treatment with minimal toxicity. (J Am Acad Dermatol 2001;45:S176-82.)
Le texte complet de cet article est disponible en PDF. This article is part of a supplement sponsored by Roche Dermatologics Inc. The conference “Isotretinoin: A State-of-the-Art Conference” was supported by Roche. |
Vol 45 - N° 5
P. S176-S182 - novembre 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?