Cellular and immunologic mechanisms in atopic dermatitis - 02/09/11
Abstract |
Atopic dermatitis is a chronic inflammatory skin disease that is frequently associated with respiratory allergies. Atopic dermatitis develops as a result of a complex interrelationship of environmental, immunologic, genetic, and pharmacologic factors. Efforts to understand the relative contributions of these factors have led to research seeking to identify the relevant effector cells and mediators involved in the pathogenesis of atopic dermatitis. These factors include the pattern of local cytokine release, the differentiation of helper T cells, multiple roles of IgE, skin-directed cell responses, infectious agents, and superantigens. This article reviews these cellular and immunologic mechanisms underlying atopic dermatitis and discusses how an understanding of their role in the inflammatory process may lead to improved treatments for atopic dermatitis.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AD, cAMP-PDE, CD, GM-CSF, IFN, IgE, IL, LPR, PBMC, PDE, PGE2, TNF
| * | Supported in part by Public Health Services Research Grants HL36577, AR41256, HL37260, and 5 M01 RR00051. This article is part of a supplement sponsored by Fujisawa Healthcare, Inc. |
Vol 44 - N° 1S1
P. S1-S12 - janvier 2001 Retour au numéro
- Current management and therapy of atopic dermatitis
- Susan J. Tofte, Jon M. Hanifin
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