Nail involvement in pemphigus vulgaris - 05/09/11
Abstract |
Nail involvement in pemphigus vulgaris is relatively rare. We describe a case of severe pemphigus involving both the skin and oral mucosa in which an acute exacerbation was preceded by the onset of nail involvement of all 4 extremities. Nail involvement occurred in the form of hemorrhagic paronychia of multiple digits. Oral, cutaneous, and nail manifestations of the disease were all well controlled by systemic therapy. A review of the literature on nail involvement in pemphigus reveals that this involvement may be manifested in multiple ways, with chronic paronychia and onychomadesis being the most common. Involvement of the nail occurs most frequently either as part of the initial presentation, or just before or concurrent with a flare of pre-existing disease. Nail involvement, when it occurs, is usually present when the disease is severe. Topical therapy is insufficient, and systemic therapy is warranted. In the majority of cases, nail recovery is complete, with no residual damage. (J Am Acad Dermatol 2000;43:529–35.)
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Supported in part by grants from the Pemphigus Foundation and IOIMS Kuwait. |
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Reprint requests: A. Razzaque Ahmed, MD, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Ave, Room I-217, Boston, MA 02115. |
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J Am Acad Dermatol 2000;43:529–35. |
Vol 43 - N° 3
P. 529-535 - septembre 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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