CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy): Diagnostic skin biopsy changes determined by electron microscopy - 05/09/11
Abstract |
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a familial vascular disorder associated with migraines, recurrent ischemic strokes, and early-onset multiinfarct dementia. The diagnosis of CADASIL is made ultrastructurally by finding characteristic granular, electron-dense, osmiophilic material attached to vascular smooth muscle cells. These changes have been found in brain, skeletal muscle, nerve, and skin. We describe a woman with CADASIL diagnosed on the basis of brain and skin electronmicroscopic findings. Dermatologists and dermatopathologists need to be aware of this disorder because characteristic electronmicroscopic changes on a skin biopsy specimen are diagnostic. (J Am Acad Dermatol 2000;43:1125-7.)
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Reprint requests: John S. Walsh, MD, Department of Dermatology, Mayo Clinic Jacksonville, 4500 San Pablo Rd, Jacksonville, FL 32224. |
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J Am Acad Dermatol 2000;43:1125-7. |
Vol 43 - N° 6
P. 1125-1127 - décembre 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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