Prognostic value of Ki-67 expression in localized cutaneous malignant melanoma - 05/09/11
Abstract |
Background: The proliferative activity of some tumors is related to the development of metastatic disease and survival. Thus it could be used as a potential prognostic variable. Objective: The purpose of this study was to determine the prognostic value of the Ki-67 index and of a “proliferation-based prognostic index” (PBPI, derived as tumor thickness × Ki-67 index/100) in localized cutaneous malignant melanoma (CMM). Methods: The Ki-67 index (percent of total tumor nuclei) was determined in a series of 84 localized CMMs, with the use of the alkaline phosphatase-antialkaline phosphatase labeling method in formalin-fixed, paraffin-embedded material, and was correlated with other prognostic variables. Survival analysis was performed to determine whether the Ki-67 index and the PBPI could be predictive of metastatic spread or recurrent disease. A stratified analysis of these two parameters according to the tumor thickness was done. Results: An association among the Ki-67 index and location, Clark level, tumor thickness and stage, and prognostic index was detected. Increased Ki-67 index and PBPI were associated with poorer overall survival (P = .03 and P < .0001, respectively) and disease-free survival (P = .01 and P < .0001, respectively). However, after stratification for thickness, only the PBPI showed independent prognostic significance, restricted to tumors thicker than 4 mm (P = .03). Conclusion: The determination of the PBPI in CMM conveys prognostic information for localized thick (>4 mm) CMM, identifying two groups of patients with distinct outcome. (J Am Acad Dermatol 2000;43:991-1000.)
Le texte complet de cet article est disponible en PDF.Abbreviations : AJCC:, CMM:, DFS:, OS:, PBPI:, PI:
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Supported by a grant from the Comissão de Fomento de Investigação em Cuidados de Saúde, Ministério da Saúde, Portugal (Project No. 74/97). |
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Reprint requests: Rui Henrique, MD, Serviço de Anatomia Patolõgica, Instituto Português de Oncologia de Francisco Gentil—Centro Regional do Porto, Rua Dr António Bernardino Almeida, 4200-072 Porto, Portugal. E-mail: rmfhenrique@netc.pt. |
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J Am Acad Dermatol 2000;43:991-1000. |
Vol 43 - N° 6
P. 991-1000 - décembre 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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