Alterations in HIV expression in AIDS patients with psoriasis or pruritus treated with phototherapy - 07/09/11
Abstract |
Background: Ultraviolet light (UVL) upregulates HIV transcription in vitro and in transgenic mice. AIDS-associated psoriasis and pruritus respond to phototherapy. Objective: Our goal was to determine the effect of phototherapy on viral load and immunologic parameters in HIV-positive patients. Methods: T cell subsets, p24, plasma cytokines, serum or plasma HIV-RNA, dosage, and antivirals were assessed in HIV-positive patients and negative controls receiving 6 weeks of phototherapy with UVB and in untreated controls. Results: Phototherapy improved skin conditions without significantly affecting T cell numbers. Plasma p24 increased 2-fold (P = .055) and HIV-RNA levels 4-fold (P = .022) 6 weeks from baseline in patients who entered the trial before March 1995. Later patients who were mostly receiving combination antiviral therapy showed a 4-fold reduction in serum HIV-RNA (P = .012) at 2 weeks. The effect of UVB on viral load at 6 weeks was dependent on the baseline level (P = .006). IL-10 increased and was inversely related to HIV-RNA levels (P = .0267). Conclusion: Phototherapy is associated with HIV load alterations, depending on patients’ initial HIV-RNA, antiviral therapy, skin type, and UVL dosage. (J Am Acad Dermatol 1999;40:48-60.)
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Supported by NIAMS grant AR39915 (to M. D., D. E. L.), a supplement to the M. D. Anderson Cancer Center Core grant (CA-16672-22) (to M. D.), and the Center for AIDS Research, Baylor College of Medicine. |
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Reprint requests: Madeleine Duvic, MD, Section of Dermatology—Box 28, M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030. |
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0190-9622/99/$8.00 + 0 16/1/94451 |
Vol 40 - N° 1
P. 48-60 - janvier 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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