Effect of colchicine in the subcorneal pustular dermatosis type of IgA pemphigus - 07/09/11
Abstract |
Background: IgA pemphigus of the subcorneal pustular dermatosis (SPD) type is characterized by subcorneal acantholysis and by an abundance of neutrophils, making colchicine a reasonable pharmacologic option for treatment. Objective: We attempted to determine the efficacy of colchicine in the treatment of SPD-type IgA pemphigus. Methods: Two patients with SPD-type IgA pemphigus were treated with colchicine 1.5 mg/day as monotherapy. Results: A sustained clinical response was achieved within 2 to 3 weeks of therapy. Relapses were noted each time colchicine was stopped. Conclusion: Colchicine should be considered in the treatment of SPD-type IgA pemphigus. (J Am Acad Dermatol 1999;40:91-4.)
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Reprint requests: E. Hodak, MD, Department of Dermatology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel. |
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0190-9622/99/$8.00 + 0 16/1/93687 |
Vol 40 - N° 1
P. 91-94 - janvier 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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