The antiangiogenic agents TNP-470 and 2-methoxyestradiol inhibit the growth of angiosarcoma in mice - 07/09/11
Abstract |
Background: Endothelial malignancies, such as angiosarcoma and hemangioendothelioma, are often resistant to chemotherapy and surgery, and may result in death. Improved means of therapy are needed for these disorders. Objective: We wanted to determine whether angiosarcoma can be treated with angiogenesis inhibitors in mice. Methods: Mice were inoculated with a cell line that gives rise to angiosarcoma and were treated with the angiogenesis inhibitors 2-methoxyestradiol and TNP-470. Response to therapy was monitored by measurement of tumors. Results: TNP-470 caused an 84% reduction in tumor size, and 2-methoxyestradiol caused a 68% reduction in tumor size. Conclusion: Angiogenesis inhibitors are highly effective in treatment of angiosarcoma in mice. Clinical trials of these agents in humans with angiosarcoma and hemangioendothelioma are warranted. (J Am Acad Dermatol 1999;40:925-9.)
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 | Supported by a Howard Hughes Postdoctoral Fellowship (to J. L. A.), a grant from the Society for Pediatric Dermatology, the Thomas B. Fitzpatrick Award from the KAO Corporation, grant to Children’s Hospital from EntreMed Inc, Rockville, Md, and National Institutes of Health grant RO3AR44947. |
| Reprint requests: Jack L. Arbiser, MD, PhD, Department of Dermatology, Emory University School of Medicine, WMB 5309, Atlanta, GA 30322. E-mail address: jarbise@emory.edu. |
 | 0190-9622/99/$8.00 + 0 16/1/96741 |
Vol 40 - N° 6
P. 925-929 - juin 1999 Retour au numéro
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