Detection of human papillomavirus type 10 DNA in eccrine syringofibroadenomatosis occurring in Clouston’s syndrome - 07/09/11
Abstract |
Syringofibroadenomatosis is often associated with an underlying condition such as diabetes mellitus or hidrotic ectodermal dysplasia. By reason of these associations, a reactive or hamartomatous cause is suspected. We report a case of a 71-year-old woman with Clouston’s syndrome in whom progressive multiple palmoplantar syringofibroadenomas developed over a 10-year period. The syringofibroadenomas formed flat-topped papules simulating verruca plana; the widespread distribution and chronic progressive course resembled epidermodysplasia verruciformis. Contiguous with the syringofibroadenoma’s characteristic epithelial-stromal proliferation were epidermal changes of verruca plana. Evidence of human papillomavirus (HPV) infection was verified by immunolabeling with antibodies to bovine papillomavirus type 1 and detection of HPV 10 viral DNA by means of polymerase chain reaction. Rather than a hamartomatous process, these findings suggest that syringofibroadenomas occurring in the setting of Clouston’s syndrome could represent an HPV-induced epithelial proliferation. (J Am Acad Dermatol 1999;40:259-62.)
Le texte complet de cet article est disponible en PDF.Plan
Reprint requests: J. Andrew Carlson, MD, Division of Dermatology and Dermatopathology, Albany Medical College A-81, Albany, NY 12208. |
|
0190-9622/99/$8.00 + 0 16/54/94745 |
Vol 40 - N° 2
P. 259-262 - février 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?