Nasal and nasal-type natural killer/ T–cell lymphoma - 07/09/11
Abstract |
Nasal and nasal-type natural killer (NK)/T-cell lymphomas follow an aggressive course and have a poor prognosis. Recent pathologic studies suggest that the disease is a malignant proliferation of NK cells, which often express CD56. An association with the Epstein-Barr virus has also been reported. Skin involvement occurred in each of the 3 patients studied. Radiation therapy provided some benefit to the patients in the early stages. Conventional chemotherapies were not effective. To overcome this multiple-drug resistance of the tumor cells, cyclosporine and high-dose chemotherapy was combined with peripheral-blood stem-cell transplantation. The average life span from the onset of the disease for our patients was 9.6 months. Further improvement in the management of nasal and nasal-type NK/T-cell lymphomas is necessary. (J Am Acad Dermatol 1999;40:268-272.)
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Reprint requests: Satoshi Hirakawa, MD, Department of Dermatology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. |
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0190-9622/99/$8.00 + 0 16/54/94732 |
Vol 40 - N° 2
P. 268-272 - février 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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