Recurrence rate of hirsutism after 3 different antiandrogen therapies - 07/09/11
Abstract |
Background: Although antiandrogens are frequently and successfully used to treat hirsutism, little attention has been paid to optimal duration of treatment and recurrence rate after cessation of therapy. Objective: Our purpose was to determine the recurrence rate of hirsutism after 3 different antiandrogen therapies. Methods: Eighty-one hirsute women referred to a tertiary hirsutism clinic were assigned to one of three regimens: spironolactone 100 mg/day with an oral contraceptive, cyproterone acetate 50 mg/day on days 1 to 10 with an oral contraceptive, or flutamide 250 mg twice a day. Hirsutism scores according to the Ferriman-Gallwey scoring system and endocrine parameters were evaluated before, during, and 1 year after withdrawal of treatment regimens. Results: Hirsutism scores decreased significantly and similarly in spironolactone, flutamide, and cyproterone acetate treatment groups. However, 1 year after withdrawal of treatment in all antiandrogen therapy groups, hirsutism returned. Conclusion: Antiandrogens are effective in the treatment of hirsutism. However, cessation of antiandrogen therapy is followed by recurrence. (J Am Acad Dermatol 1999;41:64-8.)
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Reprint requests: Mithat Erenus, MD, Hamam Sokak 94/4A, 81080 Caddebostan Istanbul, Turkey. E-mail: erenus@superonline.com.tr. 2 |
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0190-9622/99/$8.00 + 0 16/1/97583 |
Vol 41 - N° 1
P. 64-68 - juillet 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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