Primary cutaneous B-cell lymphoma with a dermatomal distribution - 07/09/11
Abstract |
Primary cutaneous B-cell lymphomas (CBCLs) are indolent lymphoproliferative skin disorders with the only exception of the variant arising on the legs, which is characterized by a more aggressive clinical course. We report a case of CBCL unusual in that it presented with a dermatome-like distribution and showed early peripheral lymph node involvement. The other noteworthy finding is that rearrangement of the bcl-2 gene was detected by polymerase chain reaction in skin tissue samples. The bcl-2 rearrangement, which is usually absent in the classic CBCLs, is likely to play a role in the aggressive clinical behavior of the tumor, although further studies are necessary to confirm it. The hypothesis of a virus causing the dermatomal presentation is intriguing but there is no proof for such speculation at this point. (J Am Acad Dermatol 1999;41:884-6.)
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This supplement is made possible through an educational grant from Ortho Dermatological to the American Academy of Dermatology. |
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Reprint requests: Angelo V. Marzano, MD, Istituto di Scienze Dermatologiche, Via Pace 9, 20122 Milano-Italy. |
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0190-9622/99/$8.00 + 0 16/4/98956 |
Vol 41 - N° 5S
P. 884-886 - novembre 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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