High-dose UVA1 therapy for atopic dermatitis: Results of a multicenter trial - 09/09/11
Abstract |
Background: The results of an open, single-center study suggested that phototherapy with high doses of UVA1 radiation (UVA1R; 340-400 nm) is effective for acute, severe exacerbations of atopic dermatitis (AD). Objective: The purpose of this study was to assess the effectiveness of high-dose UVA1 phototherapy for acute, severe AD in a randomized multicenter trial in direct comparison with topical glucocorticoid therapy. Methods: Patients were treated with high-dose UVA1R (10 days, 130 J/cm2 /day; n = 20), topically with fluocortolone (10 days, 1 x daily; n = 17), or with UVA-UVB therapy (10 days, 1 x daily, minimal erythema dose–dependent; n = 16). Results: With a clinical scoring system, significant differences in favor of high-dose UVA1R and fluocortolone therapy were observed (p < 0.0001), as compared with UVA-UVB therapy. At day 10, high-dose UVA1R was superior to fluocortolone (p < 0.002) therapy. Serum levels of eosinophil cationic protein and the blood eosinophil count were significantly reduced after high-dose UVA1 or fluocortolone, but not UVA-UVB therapy. Conclusion: This study confirms the therapeutic effectiveness of high-dose UVA1 monotherapy for treatment of severe exacerbations of AD. (J Am Acad Dermatol 1998;38:589-93.)
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Reprint requests: Jean Krutmann, MD, Professor of Dermatology, Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University, Moorenstr. 5, D-40225 Düsseldorf, Germany. |
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0190-9622/98/$5.00 + 0 16/1/88399 |
Vol 38 - N° 4
P. 589-593 - avril 1998 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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