Topical tretinoin is established as an effective treatment for photoaging. Yet some confusion still exists about the proper way to use this medication, confusion that can misguide physicians in their clinical approaches and patients in their treatment regimens. Most of the misinformation about tretinoin has been perpetuated from the early days of the drug, when its efficacy for treating the effects of photoaging was still in dispute. Significant advances in clinical and basic research in this area have dispelled much of the confusion, clearing the way for an evidence-based medical approach to tretinoin therapy for photoaging. This review summarizes recent relevant advances in tretinoin therapy to guide physicians in treating patients with this safe and effective hormone. To date, tretinoin remains the only therapeutic agent proved to repair photodamage. (J Am Acad Dermatol 1998;39:S55-61.)Le texte complet de cet article est disponible en PDF.
| Supported in part by the Babcock Dermatological Research Fund and a research agreement with Johnson & Johnson Corporation.
| Reprint requests: Sewon Kang, MD, 1910 Taubman Center, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0314.
| 0190-9622/98/$5.00 + 0 16/0/91349