Split-face comparison of adapalene 0.1% gel and tretinoin 0.025% gel in acne patients - 11/09/11
Abstract |
Background: Adapalene is a new naphthoic acid derivative developed for the topical treatment of acne vulgaris.
Objective: We compared the skin tolerance of adapalene 0.1% gel with tretinoin 0.025% gel in subjects with acne.
Methods: Fifteen acne patient volunteers were enrolled in this investigator-masked, left-right comparison, randomized, controlled, intraindividual study. Adapalene 0.1% gel and tretinoin 0.025% gel were applied once a day to one half-face by the volunteers for 14 consecutive days. Clinical signs (erythema, desquamation, papules, vesicles, edema) and subjective symptoms (tightness, pruritus, burning) were evaluated and scored daily except on weekends.
Results: Adapalene 0.1% gel was better tolerated than tretinoin 0.025% gel. The overall mean score calculated from all features combined was significantly higher with tretinoin gel than with adapalene gel ( p = 0.002).
Conclusion: Adapalene 0.1% gel was significantly less irritating than tretinoin 0.025% gel when tested in acne patients. (J Am Acad Dermatol 1997;36:S110-2.)
Le texte complet de cet article est disponible en PDF.Plan
 | Reprint requests: Alan Clucas, MRCP, CIRD Galderma, 635 Route des Lucioles, 06902 Sophia Antipolis Cedex, France. |
| 0190-9622/97/$5.00 + 0 16/0/81185 |
Vol 36 - N° 6S
P. S110-S112 - juin 1997 Retour au numéro
Article précédent
- Adapalene 0.1% gel has low skin-irritation potential
- Michèle Verschoore, Michel Poncet, Janusz Czernielewski, Valérie Sorba, Alan Clucas, From CIRD Galderma, Sophia Antipolis.
- Skin tolerance of adapalene 0.1% gel in combination with other topical antiacne treatments
- Danièle Caron, Valérie Sorba, Alan Clucas, Michèle Verschoore, From CIRD Galderma, Sophia Antipolis.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?