Successful treatment of Schamberg's disease with pentoxifylline - 11/09/11
Abstract |
Three patients with Schamberg's disease were treated with pentoxifylline, 300 mg daily for 8 weeks. A significant response was observed within 2 to 3 weeks. One patient had recurrence after discontinuation of this treatment; but promptly responded to resumption of therapy. No adverse effects were noted in any patients. We investigated the expression pattern of adhesion molecules in relation to perivascular accumulation of lymphocytes in specimens obtained before and after treatment with pentoxifylline in these patients. Our results suggest that pentoxifylline exerts its therapeutic effects on Schamberg's disease at the level of T-cell adherence to endothelial cells and keratinocytes. (J Am Acad Dermatol 1997;36:827-30.)
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This article is made possible through an educational grant from the Dermatological Division, Ortho Pharmaceutical Corporation. |
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Reprint requests: Yoko Kano, MD, Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181, Japan. |
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0190-9622/97/$5.00 + 0 16/4/78478 |
Vol 36 - N° 5S
P. 827-830 - mai 1997 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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