A wide range of infectious, neoplastic, and inflammatory dermatoses can affect the glans penis or prepuce. Some are unique to the genitalia. Other more common dermatoses may have a unique appearance when they involve genital skin and mucosa. A thorough understanding of regional anatomy and a systematic diagnostic approach are helpful in the management of a refractory penile dermatosis. We review embryology and regional anatomy, drug-induced eruptions, allergic and irritant dermatitis, infection, neoplasia, and traumatic and inflammatory dermatoses as they relate to the glans and prepuce. Our discussion focuses on the clinical features, office laboratory studies, and histopathologic findings that assist in diagnosis and treatment. (J Am Acad Dermatol 1997;37:1-24.)

Learning objective: At the conclusion of this learning activity, participants should be able to recognize common dermatoses on the glans or prepuce, recognize dermatoses that are unique to the glans and prepuce, and use appropriate treatment for penile dermatoses.