Neonatal lupus erythematosus: Analysis of HLA class II alleles in mothers and siblings from seven Japanese families - 11/09/11
From the Departments of Dermatologya and Pediatrics,b Nara Medical University, and the Department of Maternal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health.c
Abstract |
Background: Neonatal lupus erythematosus (NLE) is a syndrome characterized by dermatitis and congenital heart block. The disease is mostly associated with transplacental passage of maternal anti-Ro(SS-A) or anti-La(SS-B) antibodies. Maternal HLA-DR3 and DQ2 alleles are associated with NLE in white and North American black populations.
Objective: We sought evidence of a potential genetic disposition to NLE in mothers with a relatively homogeneous ethnic background.
Methods: Class II human major histocompatibility complex HLA-DRB1, DQA1, DQB1, and DPB1 alleles were determined by polymerase chain reaction–restriction fragment length polymorphism in anti-Ro(SS-A)–positive mothers as well as in infants from seven Japanese families with siblings concordant or discordant for disease expression of NLE.
Results: All seven mothers had two or three DQ alleles of DQA1 and DQB1 possessing specific amino acid residues, which are reportedly associated with anti-Ro(SS-A) autoantibody response in white and black populations. There was no class II HLA profile that distinguished disease manifestations of NLE in infants.
Conclusion: The HLA class II allele associations with anti-Ro(SS-A) autoantibodies that have been noted in other ethnic groups were also found in Japanese anti-Ro(SS-A)–positive mothers whose infants had NLE, suggesting shared susceptibility factors across racial barriers in maternal predisposition to Ro(SS-A) autoimmune response.
(J Am Acad Dermatol 1997;36:186-90.)
Le texte complet de cet article est disponible en PDF.Plan
Supported in part by grant 06670876 from the Ministry of Education, Science, and Culture of Japan (to Dr. Miyagawa). |
|
Reprint requests: Sachiko Miyagawa, MD, Department of Dermatology, Nara Medical University, Kashihara City, Nara 634, Japan. |
|
0190-9622/97/$5.00 + 0 16/1/77505 |
Vol 36 - N° 2
P. 186-190 - février 1997 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?