One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: A multicenter, double-blind trial - 11/09/11
From the Department of Dermatology, Yale University School of Medicine, New Havena; University of Texas Health Sciences Center, San Antoniob; the Department of Dermatology, University Hospitals of Clevelandc; Boulder Medical Centerd; J and S Studies, Bryane; Clinical Research Specialists, Inc., Santa Monicaf; Dermatology Research Associates, Cincinnatig; International Dermatology Research, Inc., Miamih; Midwest Cutaneous Research Corporation, Clinton Townshipi; and Northwest Medical Center, Atlanta.j
Abstract |
Background: Butenafine hydrochloride, a benzylamine derivative with potent antifungal activity, has been used in Japan to treat superficial fungal diseases.
Objective: We evaluated the safety and efficacy of twice-daily butenafine versus its vehicle in the treatment of interdigital tinea pedis in a multicenter, randomized, double-blind, parallel-group trial.
Methods: A total of 402 patients with interdigital tinea pedis and a positive potassium hydroxide examination were enrolled. Of the 271 patients who had culture-confirmed tinea pedis and were assessed for efficacy, 132 applied butenafine and 139 applied vehicle twice daily for 1 week. Patients were assessed for mycologic cure, effective treatment, overall cure, and mycologic/clinical cure.
Results: The rates of all four end points were significantly higher with butenafine than with vehicle 5 weeks after treatment ended. Rates of mycologic cure and effective treatment with butenafine were significantly higher than with vehicle at cessation of treatment. Adverse events to treatment occurred in less than 1% of patients treated with butenafine and 2% of patients who applied vehicle.
Conclusion: Butenafine applied twice daily for 1 week is highly effective in treating interdigital tinea pedis.
(J Am Acad Dermatol 1997;36:S15-19.)
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Vol 36 - N° 2
P. S15-S19 - février 1997 Retour au numéro
Article précédent
- Treatment of interdigital tinea pedis with a 4-week once-daily regimen of butenafine hydrochloride 1% cream
- Eduardo Tschen, Boni Elewski, David C. Gorsulowsky, David M. Pariser
- Butenafine 1% cream in the treatment of tinea cruris: A multicenter, vehicle-controlled, double-blind trial
- Jack L. Lesher, Dennis E. Babel, Daniel M. Stewart, Terry M. Jones, Lewis Kaminester, Mitchel Goldman, James S. Weintraub
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