Regulation of disease susceptibility: Decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis - 11/09/11
Abstract |
The development of restricted cytokine profiles by subsets of CD4+ T cells is a pivotal point in the regulation of immune responses. T cells producing Th1 cytokines (IL-2 and interferon-γ) induce cell-mediated immunity, whereas T cells producing Th2 cytokines (IL-4, IL-5, and IL-10) play a prominent role in the induction of humoral immunity. We examined a group of patients with multiple sclerosis, a disease caused by excess production of Th1 cytokines in myelin-reactive T cells, and control patients with noninflammatory neuroconvulsive disorders, for the presence of allergic disease, which is caused by excess production of Th2 cytokines in allergen-specific T cells. The patients with multiple sclerosis had significantly fewer allergic symptoms, a lower number of positive allergen-specific IgE test results, and lower composite allergy indexes than control subjects. These results demonstrate that the prevalence of IgE-mediated allergic disease is decreased in a group of patients with multiple sclerosis and support the hypothesis that genetic factors that promote susceptibility to Th1-mediated inflammatory disease in human beings protect against the development of Th2-mediated disease. (J ALLERGY CLIN IMMUNOL 1996;97:1402-8.)
Le texte complet de cet article est disponible en PDF.Keywords : Cytokine regulation, CD4+ T cells, autoimmune disease, Th1, Th2, allergic disease, multiple sclerosis
Abbreviations : IFN-γ:, MS:
Plan
From aDepartment of Pediatrics and bDepartment of Neurology, Stanford University, Stanford; and cMAST Immunosystems, Mountain View. |
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Supported by grants RO1AI26322, RO1AI24571, and KO7AI01026 from the National Institutes of Health, U.S. Public Health Service, and the Janssen Fellowship through the American Academy of Allergy Asthma and Immunology. |
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Reprint requests: Dale T. Umetsu, MD, PhD, Department of Pediatrics, Room H307, Stanford University, Stanford, CA 94305-5119. |
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0091-6749/96 $5.00 + 0 1/1/72531 |
Vol 97 - N° 6
P. 1402-1408 - juin 1996 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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