Successful treatment of generalized lichen planus with recombinant interferon alfa-2b - 12/09/11
Doi : 10.1016/0190-9622(95)90427-1
Axel Hildebrand, MD a, b, Gerhard Kolde, MD a, b, 
, Thomas A Luger, MD a, b, Thomas Schwarz, MD ⁎, a, b
, Thomas A Luger, MD a, b, Thomas Schwarz, MD ⁎, a, b a Department of Dermatology, University of Münster, School of Medicine, Münster, Germany.
b Ludwig Boltzmann Institute for Cellbiology and Immunobiology of the Skin, University of Münster, School of Medicine, Münster, Germany.
1Reprint requests: Thomas Schwarz, MD, Department of Dermatology, University of Münster, Von-Esmarch-Str. 56, D-48149 Münster, Germany.
Abstract |
Three patients with generalized lichen planus were treated with interferon alfa-2b. The therapy was tolerated well by all patients with only minor side effects. A response was observed within 2 to 3 weeks. Itching and erythema decreased first, followed by gradual flattening and disappearance of papules and plaques after 8 to 10 weeks of treatment. After 12 weeks, therapy was discontinued after stepwise dosage reduction. In two patients, minor lesions recurred during dosage reduction. Both flares were controlled by readministration of interferon.
Le texte complet de cet article est disponible en PDF.© 1995
Publié par Elsevier Masson SAS.
Vol 33 - N° 5P2
P. 880-883 - novembre 1995 Retour au numéro
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