Efficacy of mycophenolate mofetil in antimalarial-resistant cutaneous lupus erythematosus - 14/09/11
, Christopher Hansen, MD b, Melissa I. Costner, MD c
Reprint requests: Bryan Gammon, MD, Department of Dermatology, Northwestern University, 676 N St Clair, Suite 1600, Chicago, IL 60611.Abstract |
Background |
Mycophenolate mofetil (MMF) is an immunomodulatory drug shown to be effective in the treatment of systemic lupus erythematosus. Several anecdotal reports have suggested that MMF may be efficacious in the treatment of cutaneous lupus erythematosus (CLE).
Objectives |
Our objective was to summarize and report our experience with the use of MMF in patients with CLE recalcitrant to antimalarial therapy.
Methods |
We retrospectively analyzed our open-label observations of 24 patients with CLE refractory to antimalarial therapy. The records of all patients visiting the Rheumatic Skin Disease Clinic at the University of Texas Southwestern Medical Center at Dallas from January 1, 2001, to July 1, 2006, were reviewed.
Results |
MMF was tolerated well and, in conjunction with other therapies, was highly effective in the treatment of antimalarial-resistant CLE. With the addition of MMF to the existing regimen, a majority of patients achieved full control of disease signs and symptoms. All patients experienced some degree of improvement.
Limitations |
This is an open-label retrospective review. Severity of disease was assessed by qualitative assessment of the clinician. MMF was not used as monotherapy.
Conclusions |
Our results indicate that MMF, used as an additional agent in conjunction with standard therapy, is both well tolerated and efficacious in the treatment of refractory CLE. Despite the obvious limitations of the study, we believe this represents further evidence that MMF should be considered early in the treatment of patients refractory to antimalarial therapy.
Le texte complet de cet article est disponible en PDF.Key words : antimalarials, cutaneous lupus erythematosus, discoid lupus erythematosus, immunomodulators, mycophenolate mofetil, subacute cutaneous lupus erythematosus
Abbreviations used : CLE, DLE, LE, MMF, MPA, SCLE
Plan
| Drs Gammon and Hansen contributed equally to this work. |
|
| Funding sources: None. |
|
| Conflicts of interest: None declared. |
Vol 65 - N° 4
P. 717 - octobre 2011 Retour au numéro
Article précédent
- American Board of Dermatology Examination Dates
- Characteristic purpura of the ears, vasculitis, and neutropenia–a potential public health epidemic associated with levamisole-adulterated cocaine
- Catherine Chung, Paul C. Tumeh, Ron Birnbaum, Belinda H. Tan, Linda Sharp, Erin McCoy, Mary Gail Mercurio, Noah Craft
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?