Risk factors for adverse drug events in hospitalized elderly patients: A geriatric score - 08/10/11
the IMEPAG Group1
Abstract |
Objective |
To propose a score to evaluate the risk of ADEs in hospitalized elderly patients.
Design |
This score was developed on the basis of the IMEPAG study.
Setting |
In France, in the greater Paris area in 16 geriatric rehabilitation centres.
Participants |
All individuals aged 65 years or older who experienced an ADE during the 4 weeks of the study period.
Measurements |
ADEs were detected using a standardized checklist. Separate multivariable models were constructed using any occurrence of an ADE as the outcome with stepwise logistic regression. Significant variables were included to compute the ADE risk score. The score was validated by resampling technique (bootstrap).
Results |
During the study, on 526 hospitalized patients, 152 had at least one ADE (mean age 83.6±7.9 years). Risk factors included in the final score were: number of medications (if≥7), the presence of antipsychotic treatment and recent anticoagulant. The number of drugs taken was the strongest predictor of ADEs. The final score was between zero and 34, with an ADE risk of 12% for a score≤6, 28% for a score of 7–12, 35% for a score of 13–18 and 52% for a score>18. The area under the ROC curve was 0.70 (95% CI, 0.65–0.74).
Conclusion |
We have developed and validated a simple and practical score to detect the risk of ADEs in elderly hospitalized patients. We have also proposed a classification of risk of the drugs most frequently associated with ADEs.
Le texte complet de cet article est disponible en PDF.Keywords : Adverse drug event, Elderly, Inpatients, Score
Plan
Vol 2 - N° 5
P. 284-289 - octobre 2011 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?