Subsequent primary cancers among men and women with in situ and invasive melanoma of the skin - 20/10/11
, Judy R. Rees, BM, BCh, MPH, PhD b, Carol Kosary, PhD c, Sun Hee Rim, MPH d, Jun Li, MD, MPH, PhD d, Sherri L. Stewart, PhD d
Reprint requests: Appathurai Balamurugan, MD, MPH, Department of Family and Preventive Medicine, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 530, Little Rock, AR 72205.Abstract |
Background |
An estimated 750,000 melanoma survivors in the United States are at increased risk of subsequent primary cancers.
Objective |
We sought to assess the risk of developing subsequent primary cancers among people with cutaneous melanoma.
Methods |
Using 1992 to 2006 data from the National Cancer Institute Surveillance, Epidemiology, and End Results Program, 40,881 people with in situ melanoma and 76,041 people with invasive melanoma were followed up (mean of 5.6 years) for the development of subsequent primary cancers. The observed number of subsequent cancers was compared with those expected based on age-/race-/year-/site-specific rates in the Surveillance, Epidemiology, and End Results population. Standardized incidence ratios (SIRs) (SIR = observed number/expected number) were considered statistically significant if they differed from 1, with an alpha level of 0.05.
Results |
After a first primary in situ melanoma, risk was significantly elevated for subsequent invasive melanoma and chronic lymphocytic leukemia among men (SIRs = 8.43 and 1.44, respectively) and women (SIRs = 12.33 and 1.79, respectively). After a first primary invasive melanoma, risk was significantly elevated for subsequent invasive melanoma, thyroid cancer, non-Hodgkin lymphoma, and chronic lymphocytic leukemia among both men (SIRs = 12.50, 2.67, 1.56, and 1.57, respectively) and women (SIRs = 15.67, 1.77, 1.42, and 1.63, respectively).
Limitations |
Case ascertainment issues particularly affecting in situ melanoma cases could affect results. The role of detection bias in the diagnoses of some subsequent cancers cannot be completely eliminated.
Conclusions |
The findings of the study should guide the development of strategies such as posttreatment surveillance, screening, and ultraviolet exposure education among melanoma survivors to improve cancer survivorship.
Le texte complet de cet article est disponible en PDF.Key words : melanoma, posttreatment surveillance, screening, subsequent primary cancer, survivors
Abbreviations used : AER, CLL, NHL, PY, SEER, SIR, UV
Plan
| Publication of this supplement to the JAAD was supported by the Division of Cancer Prevention and Control, Centers for Disease Control and Prevention (CDC). |
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| Conflicts of interest: None declared. |
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| The opinions or views expressed in this supplement are those of the authors and do not necessarily reflect the opinions, recommendations, or official position of the journal editors or the Centers for Disease Control and Prevention. |
Vol 65 - N° 5S1
P. S69.e1-S69.e9 - novembre 2011 Retour au numéro
Article précédent
- Association of cutaneous melanoma incidence with area-based socioeconomic indicators–United States, 2004-2006
- Simple D. Singh, Umed A. Ajani, Christopher J. Johnson, Katherine B. Roland, Melody Eide, Ahmedin Jemal, Serban Negoita, Rana A. Bayakly, Donatus U. Ekwueme
- Melanoma survival in the United States, 1992 to 2005
- Lori A. Pollack, Jun Li, Zahava Berkowitz, Hannah K. Weir, Xiao-Cheng Wu, Umed A. Ajani, Donatus U. Ekwueme, Chunyu Li, Brian P. Pollack
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