Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: A progression model - 14/03/12
Abstract |
Background |
Little is known about the dermoscopic features of keratinocyte skin cancer.
Objective |
We sought to determine the dermoscopic features of facial actinic keratosis (AK), intraepidermal carcinoma (IEC), moderately to poorly differentiated invasive squamous cell carcinoma (SCC), and well-differentiated SCC of the keratoacanthoma type.
Methods |
This was a retrospective analysis of dermoscopic images of histopathologically diagnosed keratinocyte skin cancer.
Results |
A total of 243 (70 AK, 71 IEC, 78 SCC, and 24 keratoacanthomas) tumors of the face from 243 patients (mean age: 71.1 years; range: 44-94 years) were analyzed. The majority of patients had a fair skin type, history of melanoma or nonmelanoma skin cancer, and multiple AK. A red pseudonetwork was significantly associated with AK (P < .001), whereas dotted/glomerular vessels, diffuse yellow opaque scales, and microerosions were significantly more prevalent among IEC (P < .001). Hairpin vessels, linear-irregular vessels, targetoid hair follicles, white structureless areas, a central mass of keratin, and ulceration were significantly associated with invasive SCC (P < .001 for all criteria). Similar patterns as in SCC were observed among keratoacanthomas.
Limitations |
The retrospective design of our study and the lack of assessment of sensitivity and specificity of the dermoscopic criteria are limitations.
Conclusions |
Based on our findings we propose a progression model of facial AK developing into IEC and invasive SCC.
Le texte complet de cet article est disponible en PDF.Key words : actinic keratosis, dermatoscopy, nonmelanoma skin cancer, squamous cell carcinoma
Abbreviations used : AK, IEC, KA, MM, NMSC, SCC
Plan
Dr Zalaudek is currently a consultant at the Dermatology Unit, First Medical Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. |
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Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 66 - N° 4
P. 589-597 - avril 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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