Narrowband UVB treatment of progressive macular hypomelanosis - 14/03/12
Reprint requests: Hyun-Chang Ko, Department of Dermatology, School of Medicine, Pusan National University, 305, Guduk-ro, Seo-Ku, Busan 602-739, Korea.Abstract |
Background |
Little information is available on effective treatments for progressive macular hypomelanosis (PMH). To our knowledge, only one case of narrowband ultraviolet B (NB-UVB) therapy as an efficient treatment for patients with PMH has been reported in the recent literature.
Objective |
We aimed to investigate the clinical features of PMH in Koreans and to determine the therapeutic efficacy of NB-UVB therapy in the management of PMH.
Methods |
We performed an uncontrolled prospective study designed to evaluate the usefulness of NB-UVB therapy in PMH. A total of 23 patients with PMH were enrolled in the study. Of these, 17 patients underwent treatment with NB-UVB therapy once or twice weekly and were eligible for analysis. The remaining 6 patients were lost to follow-up before completion of the treatment. Repigmentation was evaluated by two dermatologists using photographic documentation.
Results |
In our trial, NB-UVB therapy was used successfully in 9 of 16 patients (56.2%), who showed more than 90% repigmentation. We found that 13 of 16 patients (81.3%) experienced at least 50% repigmentation. The repigmented sites showed an excellent color match. No signs of recurrence have been detected in 11 of these 16 patients (68.7%) up to the present time (13.2 ± 8.2 months of follow-up).
Limitations |
Our study includes a small number of subjects examined, and it was an uncontrolled and non–double-blind study.
Conclusions |
The findings of this study suggest that NB-UVB therapy is an effective and safe method for use in the treatment of PMH.
Le texte complet de cet article est disponible en PDF.Key words : narrow-band UVB, progressive macular hypomelanosis
Abbreviations used : NB-UVB, PMH
Plan
| Funding sources: None. |
|
| Conflicts of interest: None declared. |
Vol 66 - N° 4
P. 598-605 - avril 2012 Retour au numéro
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