UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin - 09/05/12
Abstract |
UVB irradiation is known to produce DNA damage at mutation hotspots in the p53 tumor suppressor gene, leading to the development of skin cancers. Mutations in the PTCH tumor suppressor gene, which is known to be responsible for the development of nevoid basal cell carcinoma syndrome, have also been identified in sporadic basal cell carcinomas (BCCs). We describe the case of an 80-year-old welder in whom 3 novel p53 mutations, as well as UV-specific PTCH mutations, were detected in two BCC samples from sun-exposed skin. The simultaneous presence of UV-specific p53 and PTCH mutations in the same BCC sample has not previously been reported. (J Am Acad Dermatol 2001;44:293-7.)
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Supported by the Skin Diseases Research Center of the Department of Dermatology (P-30, AR-4435, David Bickers, MD), College of Physicians and Surgeons of Columbia University. |
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Reprint requests: Désirée Ratner, MD, Department of Dermatology, 12th floor, 161 Fort Washington Ave, New York, NY 10032. E-mail: dr221@columbia.edu. |
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J Am Acad Dermatol 2001;44:293-7 |
Vol 44 - N° 2P1
P. 293-297 - février 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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