Toxic epidermal necrolysis: Review of pathogenesis and management - 13/05/12
, Chris Jackson, PhD b, Nadia Harun, PhD c, Alan Cooper, MBBS, FACD d
Reprint requests: Andrew Downey, MBBS, The University of Sydney, University Rd, University of Sydney NSW, Australia.Abstract |
Toxic epidermal necrolysis (TEN) is a severe cutaneous drug reaction with a mortality rate of approximately 30%. The hallmark of TEN is widespread epidermal sloughing due to keratinocyte apoptosis. Multiple genetic associations between TEN and specific ethnic populations have been determined. The pathophysiology of TEN has yet to be fully elucidated; however, current pathogenic models implicate Fas ligand, granulysin, and reactive oxygen species. The value of current therapies, such as intravenous immunoglobulin and corticosteroids, remains under evaluation.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CTL, IVIg, NK, ROS, SJS, TEN, TNF
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 66 - N° 6
P. 995-1003 - juin 2012 Retour au numéro
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