Primary solitary amyloidoma of Meckel’s cave is rare, and a bilateral location is even more rare. To the best of our knowledge, only 12 cases in the literature have described such a primary lesion, including one case of bilateral involvement of Meckel’s cave. We report here on the case of a 57-year-old woman presenting with pseudotumor masses involving both Meckel’s caves and responsible for trigeminal neuropathy. The final diagnosis of amyloidoma was made on the basis of histological examination of surgical biopsy specimens.