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The effect of race and ethnicity on patch test results - 13/06/12

Doi : 10.1067/mjd.2002.120792 
Vincent A. DeLeo, MD, Susan C. Taylor, MD, Donald V. Belsito, MD, Joseph F. Fowler, MD, Anthony F. Fransway, MD, Howard I. Maibach, MD, James G. Marks, MD, C.G.Toby Mathias, MD, James R. Nethercott, MD, Melanie D. Pratt, MD, Robert R. Reitschel, MD, Elizabeth F. Sherertz, MD, Frances J. Storrs, MD, James S. Taylor, MD
New York, New York, Kansas City, Kansas, Louisville, Kentucky, Ft Meyers, Florida, San Francisco, California, Hershey, Pennsylvania, Cincinnati, Ohio, Baltimore, Maryland, New Orleans, Louisiana, Winston-Salem, North Carolina, Portland, Oregon, and Cleveland, Ohio 
From the North American Contact Dermatitis Group, 1992-1998 

Abstract

Background: Allergic contact dermatitis is a condition that may be affected by differences in genetic and environmental factors. Race and ethnicity are possible examples of the former. Objective: The objective of this study was to examine the differences in patch test results between white and black individuals tested by the members of the North American Contact Dermatitis Group from July 1, 1992, to June 30, 1998. Methods: Patients evaluated in our patch test clinics were exposed to a standardized patch testing technique involving a standard series of 41 allergens in total. The standard series we used varied over the 6 years of the study in 2-year cycles. The series was the same at all centers during each of these 2-year cycles: 1992-94, 1994-96, and 1996-98. Over a 6-year period, our group tested 9624 patients. Of those individuals, 8610 (89.5%) were white and 1014 (10.5%) were black. Results: Allergic contact dermatitis and irritant contact dermatitis were the final diagnoses assigned by the investigators to individuals of the 2 races: 49% and 16%, respectively, for the white patients and 46% and 15%, respectively, for the black patients. In at least one of the three 2-year periods, testing in white patients revealed higher rates of sensitization to formaldehyde, glutaraldehyde, and a number of the formaldehyde-releasing preservatives, as well as lanolin, epoxy resin, thioureas, and balsam of Peru. Black patients exhibited higher rates of sensitization to para-phenylenediamine, cobalt chloride, thioureas, and p-tert-butylphenol formaldehyde resin in at least one of the 2-year periods. Conclusion: In this test population, we found no differences in the overall response rate to allergens. There were some differences between white and black patients in their response to specific allergens. These differences, although possibly related to genetic factors based on race, are more likely related to differences in allergen exposure determined by ethnicity. (J Am Acad Dermatol 2002;46:S107-12.)

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 Supported in part by a grant from Galderma Laboratories, L.P.
 This article is part of a supplement supported by Galderma Laboratories.
 Disclosures: Dr DeLeo is a clinical investigator for Galderma and Novartis. Dr Taylor is a clinical investigator for Allergan, Galderma, and Hill. She is a member of the Advisory Board for Galderma, Medicis, Proctor and Gamble, and Roche, and is a speaker for Allergan, Galderma, Medicis, Novartis, and Roche. The remaining authors attest that they have no conflicts of interest to disclose.
 †Deceased.
 Reprint requests: Vincent DeLeo, MD, St Luke's-Roosevelt Hospital Center, 1090 Amsterdam Ave, 11th Floor, New York, NY 10025.


© 2002  American Academy of Dermatology, Inc. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 46 - N° 2S2

P. S107-S112 - février 2002 Retour au numéro
Article précédent Article précédent
  • Acne vulgaris in skin of color
  • Susan C. Taylor, Fran Cook-Bolden, Zakia Rahman, Dina Strachan
| Article suivant Article suivant
  • Defining pseudofolliculitis barbae in 2001: A review of the literature and current trends
  • Patricia K. Perry, Fran E. Cook-Bolden, Zakia Rahman, Elena Jones, Susan C. Taylor

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