The dysplastic nevus: From historical perspective to management in the modern era : Part II. Molecular aspects and clinical management - 14/06/12
Abstract |
The dysplastic nevus is a discreet histologic entity that exhibits some clinical and histologic features overlapping with common nevi and melanoma. These overlapping features present a therapeutic challenge, and with a lack of accepted guidelines, the management of dysplastic nevi remains a controversial subject. Although some differences between dysplastic and common nevi can be detected at the molecular level, there are currently no established markers to predict biologic behavior. In part II of this continuing medical education article, we will review the molecular aspects of dysplastic nevi and their therapeutic implications. Our goal is to provide the clinician with an up-to-date understanding of this entity to facilitate clinical management of patients with nevi that have histologic dysplasia.
Le texte complet de cet article est disponible en PDF.Key words : common nevus, dysplasia, dysplastic nevus, melanoma, nevus
Abbreviations used : 5-FU, CN, DN, DNS, LOH, MAPK, PTEN
Plan
Dr Grossman is supported by the Department of Dermatology and the Huntsman Cancer Foundation. |
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Conflicts of interest: None declared. |
Vol 67 - N° 1
P. 19.e1-19.e12 - juillet 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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