Neutrophilic dermatosis revisited: An initial presentation of lupus? - 14/06/12
Abstract |
Background |
We report 7 patients with a distinct and unusual eruption consisting of a neutrophilic dermatosis in conjunction with lupus erythematosus (LE). The significance of these findings and their relevance to LE are discussed.
Objective |
We aimed to evaluate the significance of eruptive neutrophilic dermatosis in conjunction with LE.
Methods |
Seven original cases were collected during 10 years at a tertiary referral center, and were reviewed by a single board-certified dermatopathologist. All patient demographics were tabulated and analyzed. Eleven articles reporting 15 similar cases were obtained from a literature review.
Results |
Of a total of 7 adult patients, 14% (1 of 7) had a history of LE, whereas 86% (6 of 7) exhibited synchronous initial presentation of neutrophilic dermatosis with LE. Of note, 100% (7 of 7) of the patients exhibited cutaneous lesions on sun-exposed sites.
Limitations |
Only 7 of 400,000 cases showed this phenomenon, giving rise to the idea this may be just by chance.
Conclusions |
Our data and literature review suggest the existence of a neutrophilic dermatosis distinct from conventional Sweet syndrome that may herald conventional signs and symptoms or represent an initial presentation of cutaneous LE. This neutrophilic dermatosis may share a similar pathogenic mechanism related to ultraviolet exposure.
Le texte complet de cet article est disponible en PDF.Key words : lupus, neutrophilic dermatosis, Sweet syndrome
Abbreviations used : IL, LE, SLE, SLND, SS, UV
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 67 - N° 1
P. e29-e35 - juillet 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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