1927-nm Fractional resurfacing of facial actinic keratoses: A promising new therapeutic option - 14/12/12
, Jeremy A. Brauer, MD a, Robert Anolik, MD a, Kavitha K. Reddy, MD a, Julie K. Karen, MD a, b, Elizabeth K. Hale, MD a, b, Lori A. Brightman, MD a, Leonard Bernstein, MD a, d, Roy G. Geronemus, MD a, b, c
Reprint requests: Elliot T. Weiss, MD, Laser & Skin Surgery Center of New York, 317 E 34th St, New York, NY 10016.Abstract |
Background |
Actinic keratoses (AK) are precancerous epidermal proliferations commonly present on chronically sun-damaged skin. These lesions are among the most often treated dermatologic conditions.
Objective |
We sought to investigate the 6-month safety, tolerance, and efficacy of nonablative 1927-nm fractional resurfacing of facial AK.
Methods |
This was a prospective clinical trial of 24 individuals with facial photodamage and AK receiving up to 4 treatments with the fractionated 1927-nm nonablative thulium laser.
Results |
At 6 months, an 86.6% reduction in absolute number of lesions was noted by independent physician assessment. In addition, at this same time point, patients reported marked or noticeable improvement in overall photodamage.
Limitations |
This prospective study does not provide safety, tolerance, and efficacy data beyond 6 months of follow-up, nor does it identify the precise mechanism of action involved in AK clearance after 1927-nm resurfacing.
Conclusion |
The clinical and histologic findings, as well as the reported patient satisfaction and safety, suggest that the treatment of AK and photodamage with a fractionated 1927-nm nonablative thulium laser is a promising new therapeutic option.
Le texte complet de cet article est disponible en PDF.Key words : actinic keratosis, laser, nonablative resurfacing, photodamage, rejuvenation
Plan
| Funding sources: None. |
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| Disclosure: Drs Geronemus and Brightman are investigators with Solta Medical. Drs Weiss, Brauer, Anolik, Reddy, Karen, Hale, and Bernstein have no conflicts of interest to declare. |
Vol 68 - N° 1
P. 98-102 - janvier 2013 Retour au numéro
Article précédent
- Punch grafting of chronic ulcers in patients with laminin-332–deficient, non-Herlitz junctional epidermolysis bullosa
- Wing Yan Yuen, Janneke Huizinga, Marcel F. Jonkman
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- Moetaz El-Domyati, Talal Abd-El-Raheem, Hossam Abdel-Wahab, Walid Medhat, Wael Hosam, Hasan El-Fakahany, Mustafa Al Anwer
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