This paper presents the activity of the theme A “Modeling and simulation in biomedical research” within the GdR STIC Santé. This group has organized four scientific meetings and has managed one action, together with the theme B “Biomedical Signal and Image Processing”, during the period 2011–2012. The meetings have focused on modeling of the cardiorespiratory control, on the modeling and physiopathology of cardiovascular system and on Complex Systems in Biology and Medicine (co-organized with the GDR “Dynamique et Contrôle des Systèmes Complexes” – DYCOEC). The fourth one represents the official start of the “VPH-France” network that has been labeled by the Réseau National de Systèmes Complexes (RNSC). The SIGnal-processing and Modeling methods to Undertake Neonatal care during Development (SIGMUND) action has concerned seven hospitals and five CIC-IT (Clinical Technological Innovation Center) and has brought to the development of a regional project (Care-Premi) including three of the seven hospitals. The future works will focus: on strengthening the interactions with other topics of this GDR and with other GDRs, on application of modeling to solve real clinical heath problems, on the better acceptation of modeling by the industrial community.