Cellulite is a topographic skin change that is nearly ubiquitous in postpubertal women. Treatment remains elusive. The various treatments currently available are only partially or temporarily effective. Newer therapeutic modalities continue to evolve without much understanding of the complex nature of cellulite. The successful treatment of cellulite will ultimately depend upon our understanding of the pathophysiology of cellulite adipose tissue. Part I of this two-part series on cellulite reviews how the concept and perception of cellulite has evolved over time and its proposed etiologies. The article also focuses on the physiology of human adipose tissue, particularly regarding cellulite.

After completing this learning activity, participants should be able to differentiate adipocyte physiology between the cellulite-prone areas and other parts of the body, understand the spectrum of conventional and interventional treatment modalities available, including their modes of action and controversies that dominate and question their long-term efficacy based on published studies, and discuss newer horizons for the treatment of cellulite.