Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation - 24/04/13
Abstract |
Background |
The relationship between herpesvirus reactivation and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) is unclear.
Objective |
We sought to examine the relationship between human herpesvirus (HHV) reactivation and rash/GVHD after allo-SCT by prospective evaluation.
Methods |
Fifteen patients who had received allo-SCT underwent prospective serial examinations for human herpesvirus 6 (HHV-6), HHV-7, cytomegalovirus, and Epstein-Barr virus DNA in the blood by polymerase chain reaction and real-time polymerase chain reaction. Serum interferon gamma, interleukins 4 and 10, tumor necrosis factor alpha, and soluble interleukin 2 receptor (sIL-2R) were also measured.
Results |
In 10 of 15 patients, macular/papular eruptions were seen after allo-SCT and GVHD was diagnosed. In 8 patients with rash, HHV-6 DNA levels correlated with the cutaneous manifestation. Interleukin 10 and sIL-2R also increased in association with rash.
Limitations |
The number of patients in our study was relatively small. Not all patients were examined for cytokines and sIL-2R.
Conclusions |
HHV-6 reactivation may be involved in the pathogenesis of rash/GVHD after allo-SCT.
Le texte complet de cet article est disponible en PDF.Abbreviations used : allo-SCT, CMV, EBV, GVHD, HHV, IFN, IL, PCR, RISCT, SCT, sIL-2R, TNF
Plan
Funding sources: Health and Labour Sciences Research Grant (Research on Intractable Diseases). |
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Conflicts of interest: None declared. |
Vol 58 - N° 5
P. 802-809 - mai 2008 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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