Multiple antithrombotic agents increase the risk of postoperative hemorrhage in dermatologic surgery - 24/04/13
, Raymond G. Dufresne, MD a, Tianyu Li, MS b, Karthik Devarajan, PhD b, Clifford Perlis, MD b
Reprint requests: Nathaniel J. Jellinek, MD, Department of Dermatology, Warren Alpert Medical School of Brown University, 593 Eddy St, APC 10, Providence, RI 01903.Abstract |
Background |
Studies show that holding single antithrombotic agents perioperatively increases the risk of acute thrombotic events and does not significantly decrease the risk of bleeding complications in dermatological surgery. Recent data suggest that selected patients may benefit from combination therapy in preventing acute thrombotic events.
Objective |
We sought to evaluate postoperative bleeding complications in patients who underwent Mohs micrographic surgery while using multiple agents perioperatively compared with patients using a single agent or none at all.
Methods |
We conducted a retrospective chart review of patients treated in one academic Mohs micrographic surgery department during 1 year.
Results |
Patients taking two or more agents at the time of surgery were more likely to bleed than those taking one agent or none at all (P = .0016, Fisher’s exact).
Limitations |
Small sample size and retrospective nature were limitations.
Conclusion |
Perioperative use of more than one antithrombotic agent increases postoperative bleeding risk.
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| Funding sources: None. |
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| Conflicts of interest: None declared. |
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| Presented orally at the 2007 Annual Meeting of the American College of Mohs Micrographic Surgery and Cutaneous Oncology, Naples, Fla, May 2007. |
Vol 58 - N° 5
P. 810-816 - mai 2008 Retour au numéro
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