Immunosuppression may be present within condyloma acuminata - 24/04/13
Abstract |
Background |
Condyloma acuminatum are common lesions caused by human papillomavirus (HPV). HPV is associated with many human cancers, and a vaccine now prevents infection with high-risk HPV. However, eradication of established disease is difficult, indicating that these lesions are capable of local immunosuppression.
Objective |
This study examines the immunohistochemical staining characteristics of condyloma acuminatum lesions for markers of cellular immunity, including T-lymphocyte subsets, dendritic cells, and infected keratinocytes and markers of antigen presentation in condyloma tissue.
Methods |
Five snap-frozen, optimal cutting temperature–embedded condyloma lesions were immunostained for T-lymphocyte markers Fox P3, CD8, CD25 and molecules involved in antigen presentation.
Results |
Condylomas demonstrated hallmarks of immunosuppression, such as increased cellular interleukin-10 production, decreased expression of transporter associated with antigen presentation, CD40, and carbonic anhydrase IX, decreased dendritic cell counts, and increased T-regulatory cell infiltration.
Limitations |
This study was performed with lesions from a single center, and control tissue from the same patients was not available because of lack of patient consent.
Conclusion |
These results demonstrate that condylomas induce a local immunosuppressive environment, with deficits in antigen presentation and enhancement of immunosuppressive T-regulatory cell populations. Strategies to block this immunosuppression are required to elicit effective immune responses to HPV infection.
Le texte complet de cet article est disponible en PDF.Abbreviations used : HPV, IFN, IL, PCR, T reg
Plan
Supported by RO1 AR47901 and P30 AR42687 Emory Skin Disease Research Core Center Grant from the National Institutes of Health, a Veterans Administration Merit Award, and funding from the Jamie Rabinowitch-Davis and Minsk Foundations (Dr Arbiser). |
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Conflicts of interest: None declared. |
Vol 59 - N° 6
P. 967-974 - décembre 2008 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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