With the rise of the cosmeceutical industry, numerous formulations have surfaced with claims of reducing the clinical manifestations of photoaging. Many of these products capitalize on the positive connection the public makes with vitamins, especially with respect to their antioxidant capabilities. An impressive amount of basic science and clinical research has been conducted in both an attempt to discover novel strategies for preventing detrimental sun damage and to validate the addition of vitamins to skin care products. As dermatologists, it will be essential to provide our patients with substantiated counseling regarding the efficacy of commercial assertions. In this review, we will systematically examine the evidence supporting the use of vitamins in oral and topical formulations and provide a brief summary of the pathogenesis of photoaging. Limitations of this study include that there may be unpublished data or additional studies that may have been overlooked in our comprehensive review of this topic.Le texte complet de cet article est disponible en PDF.
Key words : antioxidant, ascorbic acid, niacin, niacinamide, pharmaceutical, photoaging, retinoid, tocopherol, ultraviolet, vitamin
Abbreviations used : FDA, MED, MMP, NAD, RAR, ROS, UV
| Funding sources: None.
| Disclosure: Dr Kim is a consultant for Allergan, Galderma, J&J, Stiefel, and Medicis, which manufacture retinoid analogues discussed in this article. Drs Zussman and Ahdout have no conflicts of interest to declare.