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Efficacy and safety of a carbon-dioxide ablative fractional resurfacing device for treatment of atrophic acne scars in Asians - 24/04/13

Doi : 10.1016/j.jaad.2009.08.051 
Woraphong Manuskiatti, MD , Daranporn Triwongwaranat, MD, Supenya Varothai, MD, Sasima Eimpunth, MD, Rungsima Wanitphakdeedecha, MD
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 

Reprint requests: Woraphong Manuskiatti, MD, Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Pran-nok Road, Bangkok 10700, Thailand.

Abstract

Background

Treatment of atrophic scars with a fractional laser resurfacing technique has demonstrated favorable outcomes, although data on the efficacy and adverse effects of this procedure in persons with dark-skinned phototypes are limited.

Objective

This study was conducted to evaluate the efficacy and safety of carbon-dioxide ablative fractional resurfacing on atrophic acne scars in Asian individuals.

Methods

Thirteen subjects (8 female and 5 male, aged 25-52 years) with skin phototype IV and atrophic acne scars were treated with 3 sessions of carbon-dioxide ablative fractional resurfacing laser on an average of 7-week interval. Objective (ultraviolet A-light video camera) and subjective (clinical evaluation by two blinded dermatologists) assessments were obtained at baseline and at 1, 3, and 6 months after the final treatment.

Results

At the 6-month follow-up, 85% of the subjects were rated as having at least 25% to 50% improvement of scars. Improvement significantly progressed from the 1-month follow-up to the 6-month follow-up (P = .002). At 1 month after 3 treatments, surface smoothness (P = .03) and scar volume (P < .001) significantly improved, compared with baseline measurements. Of the subjects, 62% rated themselves as having at least 50% improvement in their scars. Mild postinflammatory hyperpigmentation was the most common adverse effect observed in 92% of the subjects or 51% of treatment sessions, and was completely resolved in an average of 5 weeks.

Limitation

The small sample size was a study limitation.

Conclusions

Carbon-dioxide ablative fractional resurfacing appears to be effective and well tolerated for the treatment of atrophic acne scars in Asians.

Le texte complet de cet article est disponible en PDF.

Key words : ablative fractional resurfacing, Asians, atrophic acne scars, carbon dioxide, fractional photothermolysis

Abbreviations used : AFR, ALR, CO2, FP, MTZ, NAFR, PIH


Plan


 Supported by a research grant from Ellipse A/S, Hørsholm, Denmark.
 Conflicts of interest: None declared.


© 2009  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 63 - N° 2

P. 274-283 - août 2010 Retour au numéro
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