Permanent chemotherapy-induced alopecia: Case report and review of the literature - 24/04/13
, Elizabeth Blanchard, MD b, Lynne J. Goldberg, MD a
Reprint requests: Ben Tallon, MBChB, Skin Pathology Laboratory, Boston University School of Medicine, 609 Albany St, Boston, MA 02118-2515.Abstract |
Reversible alopecia following chemotherapy is well recognized and typically not evaluated by dermatologists. However, there are an increasing number of reports of permanent chemotherapy-induced alopecia, typically following high-dose chemotherapy and subsequent bone marrow transplantation. We describe an unusual case of permanent alopecia in a patient who received adjuvant chemotherapy for breast carcinoma, and not a conditioning regimen before bone marrow transplantation. A unique histologic finding of replacement of anagen hair follicles by linear columns of basaloid epithelium is reported. We review the clinical and histologic findings of permanent chemotherapy-induced alopecia and speculate on its pathogenesis.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AUC, BMT, CIA, HDC
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| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 63 - N° 2
P. 333-336 - août 2010 Retour au numéro
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