Onset of alopecia areata after Epstein-Barr virus infectious mononucleosis - 24/04/13
National Alopecia Areata Registry
Reprint requests: Madeleine Duvic, MD, University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Blvd–434, Houston, TX 77030-4009.Abstract |
Background |
The pathogenesis of alopecia areata (AA) is incompletely known. A positive family history in some points to a genetic predisposition, and discordance of the disease in identical twins suggests environmental triggers exist.
Objective |
We sought to determine whether the Epstein-Barr virus (EBV) is a possible environmental trigger for AA.
Methods |
We queried the National AA Registry for all patients who self-reported sudden onset of AA with concurrent EBV mononucleosis.
Results |
Among the 6256 individuals registered between December 2001 and August 2007, 1586 patients reported an environmental trigger—including 12 individuals who had an EBV infection within 6 months before the onset of AA.
Limitations |
This study relies on self-reported data, and not all medical records confirming EBV infections were available for review.
Conclusion |
The association between EBV and AA is worthy of further investigation.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AA, AT, AU, EBV
Plan
| Funded by the National Alopecia Areata Registry (NAAR), a National Institutes of Health– and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)–sponsored national tissue bank to collect patient samples for the purpose of investigating the underlying causes of alopecia areata. The aforementioned article is based on findings from NAAR. NAAR is funded by NIAMS. The principal investigators are Madeleine Duvic, MD; Angela Christiano, PhD, Columbia University; Maria Hordinsky, MD, University of Minnesota; David Norris, MD, University of Colorado; and Vera Price, MD, University of California. |
|
| Conflicts of interest: None declared. |
Vol 59 - N° 1
P. 137-139 - juillet 2008 Retour au numéro
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